Publications


Raphemot, R., Eubanks, A.L., Toro-Moreno, M., Geiger, R., Hughes, P.H., Lu, K., Haystead, T.A., Derbyshire, E.R.** Plasmodium PK9 Inhibitors Promote Growth of Liver-Stage Parasites. Cell Chemical Biology 2018, Accepted.


Eubanks, A.L., Perkins, M.P., Sylvester, K., Ganley, J.G., Posfai, D., Derbyshire, E.R.** In silico Screening and Evaluation of Plasmodium falciparum Protein Kinase 5 Inhibitors. ChemMedChem 2018, In press.


Posfai, D., Sylvester, K., Reddy. A., Ganley J.G., Wirth J., Cullen, Q.E., Dave, T., Kato, N., Dave, S.S., Derbyshire, E.R.** Plasmodium Parasite Exploits Host Aquaporin-3 During Liver Stage Malaria Infection. PLOS Pathogens 2018, 14, e1007057. Featured on Cover. Highlighted in news.


Ganley, J.G., Carr, G., Ioerger, T.R., Sacchettini, J.C., Clardy, J.,** Derbyshire, E.R.** Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Plasmodium-Infected Mosquitoes. ChemBioChem 2018, 19, 1590-1594. Selected as Very Important Paper. Featured on Cover.


Posfai, D., Eubanks, A.L., Keim, A.I., Lu, K.Y., Wang, G.Z., Hughes, P.F., Kato, N., Haystead, T.A., Derbyshire, E.R.** Identification of Hsp90 Inhibitors with anti-Plasmodium Activity. Antimicrobial Agents and Chemotherapy 2018, 62, e01799-17.


Ganley, J.G.*, Toro-Moreno, M.*, Derbyshire, E.R.** Exploring the Untapped Biosynthetic Potential of Apicomplexan Parasites. Biochemistry 2018, 57, 365-375.


Totzke, J., Gurbani, D., Raphemot, R., Hughes, P.F., Bodoor, K., Carlson, D.A., Eibschutz, L.S., Perkins, M.P., Eubanks, A.L., Campbell, P., Fox, D., Westover, K.**, Haystead, T.A.**, Derbyshire, E.R.** Takinib, an Exquisitely Selective Inhibitor of TAK1, Targets Pro Survival TNFa- Dependent Signaling, Inducing Apoptosis in Rheumatoid Arthritis and Breast Cancer Cell Models. Cell Chemical Biology 2017, 24, 1029-1039.


Kato, N., Comer, E., Sakata-Kato, T., Maetani, M., Bastien, J., Corey, V., Clarke, D., Derbyshire, E.R., Dornan, G., Duffy, S., Eckley, S., Koolen, K.M.J., Lewis, T., Lund, E., Riera, S.M., McPhail, J., Mitasev, B., Moss, E., Sayes, M., VanGessel, Y., Wawer, M., Yoshinaga, T., Zeeman, A., Avery, V.M., Bhatia, S.N., Burke, J.E., Catteruccia, F., Clardy, J., Clemons, P.A., Dechering, F., Duvall, J.R., Foley, M.A., Gusovsky, F., Kocken, C.H., Morningstar, M., Munoz, B., Neafsey, D., Winzeler, E.A., Wirth, D.F., Scherer, C.A., Schreiber, S.L. Diversity Synthesis Yields Novel Multistage Antimalarial Inhibitors. Nature 2016, 538, 344-349.


Raphemot, R., Posfai, D., Derbyshire, E.R.** Current Therapies and Future Possibilities for Novel Antimalarial Drug Development. Journal of Clinical Investigation 2016, 126, 2013-2020.


Raphemot, R., Lafuente-Monasterio, M., Gamo, F.J., Clardy, J., Derbyshire, E.R.** Discovery of Dual Stage Malaria Inhibitors with New Targets. Antimicrobial Agents and Chemotherapy 2016, 60, 1430-1437.


Derbyshire, E.R.**, Zuzarte-Luís, V., Magalhães, A.D., Kato, N., Sanschagrin, P.C., Wang, J., Zhou, W., Miduturu, C.V., Mazitschek, R., Sliz, P., Mota, M.M., Gray, N.S., Clardy, J.** Chemical Interrogation of the Malarial Host and Parasite Kinomes. ChemBioChem 2014, 15, 1920-1930. Featured on Cover.


Derbyshire, E.R.**, Min, J., Guiguemde, W.A., Clark, J.A., Connelly, M.C., Magalhães, A.D., Guy, R.K., Clardy, J.** Dihydroquinazolinone Inhibitors of Proliferation of Blood and Liver Stage Malaria Parasites. Antimicrobial Agents and Chemotherapy 2014, 58, 1516-1522.


**Corresponding author.

Postdoctoral and graduate publications:


Herman, J.D., Pepper, L.R., Cortese, J.F., Estiu, G., Galinsky, K., Zuzarte-Luis, V., Derbyshire, E.R., Ribacke, U., Lukens, A.K., Santos, S.A., Patel, V., Clish, C.B., Sullivan, W.J. Jr, Zhou, H., Bopp, S.E., Schimmel, P., Lindquist, S., Clardy, J., Mota, M.M., Keller, T.L., Whitman, M., Wiest, O., Wirth, D.F., Mazitschek, R. The Cytoplasmic Prolyl-tRNA Synthetase of the Malaria Parasite is a Dual-Stage Target of Febrifugine and its Analogs. Science Translational Medicine 2015, 7, 288ra77.


Derbyshire, E.R., Clardy, J. Closing in on a New Treatment for Sleeping Sickness. eLife 2013, 2, e01042. Insight.
Carr, G., Derbyshire, E.R., Caldera, E., Currie, C.R., Clardy, J. Antibiotic and Antimalarial Quinones from Fungus-Growing Ant-Associated Pseudonocardia sp. Journal of Natural Products 2012, 75, 1806-1809.


Gunn, A., Derbyshire, E.R., Marletta, M.A., Britt, R.D. Conformationally Distinct Five-Coordinate Heme-NO Complexes of Soluble Guanylate Cyclase Elucidated by Multifrequency EPR. Biochemistry 2012, 51, 8384-8390.


Fernhoff, N.B., Derbyshire, E.R., Underbakke E.S., Marletta, M.A. Heme-Assisted S-nitrosation Desensitizes Ferric Soluble Guanylate Cyclase to Nitric Oxide. Journal of Biological Chemistry 2012, 287, 43053-43062.


Derbyshire, E.R., Mazitschek, R., Clardy, J. Halofuginone Inhibition of Liver Stage Malaria. ChemMedChem 2012, 7, 844-849: Selected as Very Important Paper. Featured on Cover.


Derbyshire, E.R., Prudencio, M., Mota, M.M., Clardy, J. Liver-Stage Malaria Parasites Vulnerable to Diverse Chemical Scaffolds. Proceedings of the National Academy Science 2012, 109, 8511-8516.


Derbyshire, E.R., Marletta, M.A. Structure and Regulation of Soluble Guanylate Cyclase. Annual Review in Biochemistry 2012, 81, 533-539. Review article.


Dong, C.K., Urgaonkar, S., Cortese, J.F., Gamo, F.J., Garcia-Bustos, J.F., Lafuente, M.J., Patel, V., Ross, L., Coleman, B.I., Derbyshire, E.R., Clish, C.B., Serrano, A.E., Cromwell, M., Barker, R.H. Jr, Dvorin, J.D., Duraisingh, M.T., Wirth, D.F., Clardy, J., Mazitschek, R. Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors. Chemistry & Biology 2011, 18, 1602-1610.


Derbyshire, E.R., Mota, M.M., Clardy, J. The Next Opportunity in Anti-Malaria Drug Discovery: The Liver Stage. PLoS Pathogens 2011, 7, e1002178. Review article.


Derbyshire, E.R., Winter, M.B.*, Ibrahim, M.*, Deng, S., Spiro, T.G., Marletta, M.A. Probing Domain Function in Soluble Guanylate Cyclase. Biochemistry 2011, 50, 4281-4290: Featured article.


Ibrahim, M., Derbyshire, E.R., Soldatova, A.V., Marletta, M.A., Spiro, T.G. Soluble Guanylate Gyclase is Activated Differently by Excess NO and YC-1: Resonance Raman Spectroscopic Evidence. Biochemistry 2010, 49, 4864-4871.


Ibrahim, M., Derbyshire, E.R., Marletta, M.A., Spiro, T.G. Probing Soluble Guanylate Cyclase Activation by CO and YC-1 Using Resonance Raman Spectroscopy. Biochemistry 2010, 49, 3815-3823.


Derbyshire, E.R., Deng, S., Marletta, M.A. Incorporation of Tyrosine and Glutamine Residues into the Soluble Guanylate Cyclase Heme Distal Pocket Alters NO and O2 Binding. Journal of Biological Chemistry 2010, 285, 17471-17478.


Fernhoff, N.B.*, Derbyshire, E.R.*, Marletta, M.A. A Nitric Oxide/Cysteine Interaction Mediates the Activation of Soluble Guanylate Cyclase. Proceedings of the National Academy Science 2009, 106, 21602-21607.


Derbyshire, E.R., Fernhoff, N.B., Deng, S., Marletta, M.A. Nucleotide Regulation of Soluble Guanylate Cyclase Substrate Specificity. Biochemistry 2009, 48, 7519-7524.


Derbyshire, E.R., Marletta, M.A. Biochemistry of Soluble Guanylate Cyclase. Handbook of Experimental Pharmacology 2009, 191, 17-31. Book chapter.


Winger, J.A., Derbyshire, E.R., Lamers, M.H., Marletta, M.A., Kuriyan, J. The Crystal Structure of the Catalytic Domain of a Eukaryotic Guanylate Cyclase. BMC Structural Biology 2008, 8, 42: Highly accessed article.


Derbyshire, E.R., Gunn, A., Ibrahim, M., Spiro, T.G., Britt, R.D., Marletta, M.A. Characterization of Two Different 5-Coordinate Soluble Guanylate Cyclase Ferrous Nitrosyl Complexes. Biochemistry 2008, 47, 3892-3899.


Derbyshire, E.R., Marletta, M.A. Nitric Oxide: Biological Targets. Wiley Encyclopedia of Chemical Biology 2008, 4, 1-8. Book chapter.


Derbyshire, E.R., Marletta, M.A. Butyl Isocyanide as a Probe of the Activation Mechanism of Soluble Guanylate Cyclase: Investigating the Role of Non-Heme Nitric Oxide. Journal of Biological Chemistry 2007, 282, 35741-35748.


Martin, N.I., Derbyshire, E.R., Marletta, M.A. Synthesis and Evaluation of a Phosphonate Analogue of the Soluble Guanylate Cyclase Activator YC-1. Bioorganic and Medicinal Chemistry Letters 2007, 17, 4938-4941.


Winger, J.A.*, Derbyshire, E.R.*, Marletta, M.A. Dissociation of Nitric Oxide from Soluble Guanylate Cyclase and H-NOX Domain Constructs. Journal of Biological Chemistry 2006, 282, 897-907.


Cary, S.P.L., Winger, J.A., Derbyshire, E.R., Marletta, M.A. Nitric Oxide Signaling: No Longer Simply On or Off. Trends in Biochemical Sciences 2006, 31, 231-239. Review article.


Derbyshire, E.R., Tran, R., Mathies, R., Marletta, M.A. Characterization of Nitrosoalkane Binding and Activation of Soluble Guanylate Cyclase. Biochemistry 2005, 49, 16257-16265.


*These authors contributed equally.